Jose Luis Garcia-Lopez's iconic depictions of DC's characters defined a generation-and he's illustrated some of the most immediately recognizable tales of the Dark Knight! This incredible hardcover collection is a can't miss for any fan of Jose Luis Garcia-Lopez incredible work! Legends of the Dark Knight: Jose Luis Garcia Lopez contains Batman #272, #311, #313, #314, #318, #321, #336-337, and #353, Batman '66: The Lost Episode #1, Batman Confidental #26-28, Batman: Family #3, Batman: Dark Knight of the Round Table #1-2, Batman: Gotham Knights #10, Batman: Reign of Terror #1, DC Comics Presents #31 and #41, DC Special Series #21, Detective Comics #454, #458-459, #483, and #487, The Best of the Brave and the Bold #1-6, The Brave and the Bold #164 and #171, The Joker #4, The Untold Legend of the Batman #1-3, and World's Finest Comics #244, #255, and #258.

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

This volume offers a new understanding of the role of the media in the Portuguese Empire, shedding light on the interactions between communications, policy, economics, society, culture, and national identities. Based on an interdisciplinary approach, this book comprises studies in journalism, communication, history, literature, sociology, and anthropology, focusing on such diverse subjects as the expansion of the printing press, the development of newspapers and radio, state propaganda in the metropolitan Portugal and the colonies, censorship, and the uses of media by opposition groups. It encourages an understanding of the articulations and tensions between the different groups that participated, willingly or not, in the establishment, maintenance and overthrow of the Portuguese Empire in Angola, Mozambique, Sao Tome e Principe, Cape Verde, Guinea-Bissau, India, and East Timor.

This book offers a comprehensive coverage of process simulation and flowsheeting, useful for undergraduate students of Chemical Engineering and Process Engineering as theoretical and practical support in Process Design, Process Simulation, Process Engineering, Plant Design, and Process Control courses. The main concepts related to process simulation and application tools are presented and discussed in the framework of typical problems found in engineering design. The topics presented in the chapters are organized in an inductive way, starting from the more simplistic simulations up to some complex problems.

This volume covers the latest protocols designed to identify and characterize TEs in genomes, ancient or recently inserted. Additionally, this book includes a series of protocols designed to understand how host genomes act to regulate the activity of TEs, from elegant genetic mobilization assays to key biochemical methods. Finally, this book also includes chapters that describe how TEs can be used for biotechnological applications. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transposons and Retrotransposons: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume offers a new understanding of the role of the media in the Portuguese Empire, shedding light on the interactions between communications, policy, economics, society, culture, and national identities. Based on an interdisciplinary approach, this book comprises studies in journalism, communication, history, literature, sociology, and anthropology, focusing on such diverse subjects as the expansion of the printing press, the development of newspapers and radio, state propaganda in the metropolitan Portugal and the colonies, censorship, and the uses of media by opposition groups. It encourages an understanding of the articulations and tensions between the different groups that participated, willingly or not, in the establishment, maintenance and overthrow of the Portuguese Empire in Angola, Mozambique, Sao Tome e Principe, Cape Verde, Guinea-Bissau, India, and East Timor.

This volume rethinks the work of Jacques Ellul (1912-1994) on the centenary of his birth, by presenting an overview of the current debates based on Ellul's insights. As one of the most significant twentieth-century thinkers about technology, Ellul was among the first thinkers to realize the importance of topics such as globalization, terrorism, communication technologies and ecology, and study them from a technological perspective. The book is divided into three sections. The first discusses Ellul's diagnosis of modern society, and addresses the reception of his work on the technological society, the notion of efficiency, the process of symbolization/de-symbolization, and ecology. The second analyzes communicational and cultural problems, as well as threats and trends in early twenty-first century societies. Many of the issues Ellul saw as crucial - such as energy, propaganda, applied life sciences and communication - continue to be so. In fact they have grown exponentially, on a global scale, producing new forms of risk. Essays in the final section examine the duality of reason and revelation. They pursue an understanding of Ellul in terms of the depth of experience and the traditions of human knowledge, which is to say, on the one hand, the experience of the human being as contained in the rationalist, sociological and philosophical traditions. On the other hand there are the transcendent roots of human existence, as well as "revealed knowledge," in the mystical and religious traditions. The meeting of these two traditions enables us to look at Ellul's work as a whole, but above all it opens up a space for examining religious life in the technological society.

"Spanish Money and Banking" provides new insights into recent advances in financial and monetary history and theory, and demonstrates the significance of Spain to modern banking, monetary, and development theory. Using a comparative approach, it brings together a substantial amount of research carried out in Spain and abroad. It also contributes to scholarly debates on aspects of monetary and banking history, topics such as free vs regulated banking, metallic vs fiduciary money, specialized vs universal banking, bank- vs market-led finance, banking repression vs liberalization, the contribution of banking and money to growth, and the role of the state in financial and economic development. It also shows how financial and monetary mismanagement contributed to the decline of Spain in the early modern era, and how the development of the banking sector later on contributed to the first stirrings of development in modern Spain, especially in the 20th century, throwing light as well on the causes of the recent European crisis and the part Spain played in it.

The word consensus has been frequently used for centuries, perhaps millenia. People have always deemed it important that decisions having a long lasting impact on groups, countries or even civilizations be arrived at in a consensual manner. Undoubtedly the complexity of modern world in all its social, technological, economic and cultural dimensions has created new environments where consensus is regarded desirable. Consensus typically denotes a state of agreement prevailing in a group of agents, human or software. In the strict sense of the term, consensus means that the agreement be unanimous. Since such a state is often unreachable or even unnecessary, other less demanding consensus-related notions have been introduced. These typically involve some graded, partial or imprecise concepts. The contributions to this volume define and utilize such less demanding - and thus at the same time more general - notions of consensus. However, consensus can also refer to a process whereby the state of agreement is reached. Again this state can be something less stringent than a complete unanimity of all agents regarding all options. The process may involve modifications, resolutions and /or mitigations of the views or inputs of individuals or software agents in order to achieve the state of consensus understood in the more general sense. The consensus reaching processes call for some soft computational approaches, methods and techniques, notably fuzzy and possibilistic ones. These are needed to accommodate the imprecision in the very meaning of some basic concepts utilized in the definition of consensus as a state of agreement and as a process whereby this state is to be reached. The overall aim of this volume is to provide a comprehensive overview and analysis of the issues related to consensus states and consensual processes.

This book incorporates advances in financial and monetary history and theory and shows the relevance of Spain's story to modern banking, monetary and development theory. It studies the early development of banking and monetary institutions and shows how financial and monetary mismanagement contributed to the decline of Spain in the early modern era

This volume rethinks the work of Jacques Ellul (1912-1994) on the centenary of his birth, by presenting an overview of the current debates based on Ellul's insights. As one of the most significant twentieth-century thinkers about technology, Ellul was among the first thinkers to realize the importance of topics such as globalization, terrorism, communication technologies and ecology, and study them from a technological perspective.

The book is divided into three sections. The first discusses Ellul's diagnosis of modern society, and addresses the reception of his work on the technological society, the notion of efficiency, the process of symbolization/de-symbolization, and ecology. The second analyzes communicational and cultural problems, as well as threats and trends in early twenty-first century societies. Many of the issues Ellul saw as crucial - such as energy, propaganda, applied life sciences and communication - continue to be so. In fact they have grown exponentially, on a global scale, producing new forms of risk.

Essays in the final section examine the duality of reason and revelation. They pursue an understanding of Ellul in terms of the depth of experience and the traditions of human knowledge, which is to say, on the one hand, the experience of the human being as contained in the rationalist, sociological and philosophical traditions. On the other hand there are the transcendent roots of human existence, as well as "revealed knowledge," in the mystical and religious traditions. The meeting of these two traditions enables us to look at Ellul's work as a whole, but above all it opens up a space for examining religious life in the technological society.

Pedro Avil s P rez, Jaime Herrera Nevarez, Juan N. Guerra, Miguel ngel F lix Gallardo, Rafael Caro Quintero, Ernesto Fonseca Carrillo, Manuel Salcido Uzeta, Pablo Acosta Villarreal, Juan Jos Esparragoza Moreno, Gilberto Ontiveros Lucero, Amado Carrillo Fuentes, Joaqu n Loera Guzm n, los hermanos Arellano F lix, los hermanos Quintero Pay n, Alberto Sicilia Falc n, H ctor Luis Palma Salazar, Rafael Mu oz Talavera, Juan Garc a brego, Casimiro Campos Espinosa, Luis Medrano Garc a, Jos Alonso P rez de la Rosa, scar Malherbe, Oliverio Ch vez Araujo, Osiel C rdenas Guill n, Baldomero Medina Garza, Juan Ram n Matta Ballesteros, Pablo Escobar Gaviria, Carlos Enrique Lehder, Gonzalo Rodr guez Gacha, Jorge Luis Ochoa V zquez, Roberto Su rez G mez, Luis Malpartida, Carlos Langbert, Reynaldo Rodr guez L pez, los hermanos Rodr guez Orejuela, entre muchos otros, son los principales protagonistas de esta novela pol tico-policiaca. Aunque durante sus respectivos juicios se evit hablar de sus poderosos e influyentes c mplices, al final salieron a relucir los nombres de los pol ticos, militares y polic as como: Miguel Alem n Vald s, Luis Echeverr a lvarez, Mario Moya Palencia, Manuel Bartlett D az, Miguel Nazar Haro, Jos Antonio Zorilla P rez, Rafael Chao L pez, Rafael Aguilar Guajardo, Florentino Ventura Guti rrez, Miguel Aldana Ibarra, Manuel Ibarra Herrera, Carlos Aguilar Garza, Guillermo Gonz lez Calderoni, Emilio Mart nez Manautou, Tom s Yarrington Ruvalcaba, Leopoldo S nchez Celis, Antonio Toledo Corro, Enrique lvarez del Castillo, scar Flores S nchez, Javier Coello Trejo, Rodolfo Le n Arag n, Ra l Salinas de Gortari, Jorge Carpizo, Juan Ar valo Gardoqui, Jes s Guti rrez Rebollo, Arturo Durazo Moreno, Francisco Sahag n Baca, y de much simos personajes m s. De los expedientes de estas historias, el periodista y escritor Jos Luis Garc a Cabrera form la trama de esta su quinta novela: 1920-2000 El Pastel , un documento apegado a la dura y terrible realidad del tr fico de drogas en M xico.

Pedro Avil s P rez, Jaime Herrera Nevarez, Juan N. Guerra, Miguel ngel F lix Gallardo, Rafael Caro Quintero, Ernesto Fonseca Carrillo, Manuel Salcido Uzeta, Pablo Acosta Villarreal, Juan Jos Esparragoza Moreno, Gilberto Ontiveros Lucero, Amado Carrillo Fuentes, Joaqu n Loera Guzm n, los hermanos Arellano F lix, los hermanos Quintero Pay n, Alberto Sicilia Falc n, H ctor Luis Palma Salazar, Rafael Mu oz Talavera, Juan Garc a brego, Casimiro Campos Espinosa, Luis Medrano Garc a, Jos Alonso P rez de la Rosa, scar Malherbe, Oliverio Ch vez Araujo, Osiel C rdenas Guill n, Baldomero Medina Garza, Juan Ram n Matta Ballesteros, Pablo Escobar Gaviria, Carlos Enrique Lehder, Gonzalo Rodr guez Gacha, Jorge Luis Ochoa V zquez, Roberto Su rez G mez, Luis Malpartida, Carlos Langbert, Reynaldo Rodr guez L pez, los hermanos Rodr guez Orejuela, entre muchos otros, son los principales protagonistas de esta novela pol tico-policiaca. Aunque durante sus respectivos juicios se evit hablar de sus poderosos e influyentes c mplices, al final salieron a relucir los nombres de los pol ticos, militares y polic as como: Miguel Alem n Vald s, Luis Echeverr a lvarez, Mario Moya Palencia, Manuel Bartlett D az, Miguel Nazar Haro, Jos Antonio Zorilla P rez, Rafael Chao L pez, Rafael Aguilar Guajardo, Florentino Ventura Guti rrez, Miguel Aldana Ibarra, Manuel Ibarra Herrera, Carlos Aguilar Garza, Guillermo Gonz lez Calderoni, Emilio Mart nez Manautou, Tom s Yarrington Ruvalcaba, Leopoldo S nchez Celis, Antonio Toledo Corro, Enrique lvarez del Castillo, scar Flores S nchez, Javier Coello Trejo, Rodolfo Le n Arag n, Ra l Salinas de Gortari, Jorge Carpizo, Juan Ar valo Gardoqui, Jes s Guti rrez Rebollo, Arturo Durazo Moreno, Francisco Sahag n Baca, y de much simos personajes m s. De los expedientes de estas historias, el periodista y escritor Jos Luis Garc a Cabrera form la trama de esta su quinta novela: 1920-2000 El Pastel , un documento apegado a la dura y terrible realidad del tr fico de drogas en M xico.